Andexanet alfa is the agent FDA-approved for life-threatening bleeding associated with apixaban (Eliquis) and rivaroxaban (Xarelto), both of which are factor Xa inhibitors. Idarucizumab is a monoclonal antibody fragment that specifically binds dabigatran and its metabolites. When vitamin K is given IV, it should be administered by slow infusion to minimize risk of anaphylaxis.Īnswer B is incorrect because the reversal agent for dabigatran is idarucizumab (Praxbind). Normally, it is given when INR is > 10 and/or significant bleeding is present. Which of the following correctly matches the drug with its antidote/reversal agent? Select all that apply.īecause warfarin is a vitamin K antagonist, phytonadione (vitamin K) can be given as an antidote, making answer A correct.
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